Blood and yellow fluid spray at high pressures when they are injured, which Dog explains as them having pockets of pressurized gas inside them. Like ghouls and super mutants, ghost people are functionally immortal, however, they can die if their limbs are dismembered. They band together in groups of two to three and hide in the refuges of shadow and Cloud, striking relentlessly when prey wander too close. Their primitive minds still form some semblance of group tactics as they hunt their prey similarly to a pack of wolves. The ghost people are incredibly territorial and equally hostile and oust any intruder from the Sierra Madre. Despite this, they are in fact quite agile when necessary, often lunging and dashing at high speed.

The centuries-old stiffening hazmat suits and Cloud-related malady force them to shamble like undead creatures. Their most common hunting grounds are Salida and Puesta del Sol, especially in areas thick with the Cloud. According to Dean Domino, they collect anywhere in the Sierra Madre away from holograms and the underground service routes and ruined buildings of the Sierra Madre Villa are prime habitats for them. If they have a lair at all, it is unclear where.

They seemingly exist only to lurk through the villa ruins, forever seeking prey. Dean Domino questions whether being 'alive' applies to the ghost people, and claims there are hordes of ghost people living under the Sierra Madre's streets, comparing it to a hornet's nest. Their manner, movements, and general presence are seemingly much akin to a malignant haunting to any who have survived and fled attempts to breach the Sierra Madre. The moniker 'ghost people' can also be ascribed to the ghostly manner in which they inhabit the ruins. Virtual immortality and death only with limb amputation is also a mutation very specific to them. However, they seem to be a different mutated evolution and not simply a feral ghoul or glowing one in appearance, as their ability to use and construct weapons is still intact.

Dismembering them reveals bright, glowing blood, akin to that of a glowing one and they also shriek before attacking. Ghost people are similar to feral ghouls in several aspects. The locking mechanisms would quickly corrode when in contact with the Cloud, to the point where the hazmat suit had to be cut open with a cosmic knife, yet the suits still did not provide proper protection from the poisonous gas cloud. Incidentally, the gas leak itself was also created at Big MT, and with the hazmat suits being an 'experiment within an experiment.' The hazmat suits were bulky, nearly impossible to speak through and grew stiff with use. Hazmat suits designed specially in Big MT arrived to protect against the noxious gas. During construction, a strange gas that would evolve into the Cloud began leaking from the pipes and hospitalized a worker with severe lung and tissue damage further progress was called off until protective gear could be issued. The ghost people originate from construction workers that worked on the Sierra Madre Villa before the war. They are the only ones able to walk in and out of the Cloud unharmed. A green vapor that seems to be a by-product of the Cloud escapes and is reabsorbed continuously from their hazmat suits by means of aeration on their thighs, elbows and face mask, indicating that their mutation originates from permanent exposure to the Cloud. Ghost people are mutated humans changed forever by the Cloud, a combination of corrosive rust-like toxins unique to the Sierra Madre. вЂњ The origins of the Ghost People are a mystery, as is their strange reverence of the holographic ghosts that fill the city streets.

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